H

haloperidol 258 ff. haplotyping 54 a-helical structure 354 helix 386, 389 ff.

high throughput screening (HTS) 82, 114, 124, 135, 157, 162, 168, 180, 185, 231, 244, 294, 305 ff., 321, 402 hippuric acid 288 hippuryl-L-phenylalanine 287 f. histidine 104 f. (R)-homoproline 273 f. HPLC 44, 51, 67, 75, 82 ff., 98, 113 ff., 185 ff.,

208, 259 ff., 277, 309, 377, 381 ff., 402 ff. human gamma interferon 16 human growth hormone (hGH) 386 f., 392 f.

human serum albumine (HSA) 133 ff. human urine 45 Huntington's chorea 269 Huperzine A 194, 197 hydrophilic interaction chromatography

(HILIC) 231, 241 hydroxyl radical 361 f., 367

7-hydroxy-1-methyl quinolinium iodide (HMQI) 194

8-hydroxyquinoline 109 4-hydroxypicolinic acid 286

3-hydroxyretinoic acid

- phase II metabolite 18 hyphenation 4

IC50 77, 88f., 98ff., 140, 149, 171, 197, 200, 227 f., 260ff., 288, 334 -definition 111 identification 54, 263 immune system 388 in silico 403 in vitro 402f., 405, 415 in vivo 403, 405 f. incubation 259, 261, 271, 296 f. indicator 232 ff., 242 inflammation 388 inhibition assay 185

- lispro 357

- wild-type 357

insulin-like growth factor receptor (IGFr)

protein 74, 100 ff. internal standard (IS) 43, 270, 416 intestinal fatty acid binding protein (IFABP) 346, 353 f., 360

- wild-type (WT) 354 intracellular matrix 322 intravenous 408

ion evaporation model (IEV) 16 f.

ion intensity 35

ion mobility (IM) 116

- high field asymmetric waveform ion mobility spectrometry (FAIMS) 226

ion modulator 35 ion source 4 ff. ionic strength 352 ionization gas, methane 12 isoelectric focusing (IEF) 51 isotope 56 isotopic abundance

- hydrogen 6

- oxygen 6

isotopical labeling 42, 122, 136, 288, 291,

299, 378 IUPAC 58

k kinetic

-assay 250f., 272ff.

- first-order 70, 143

- Michaelis-Menten analysis 131

- pseudo-first order 348

- second-order 68

- study 341

l lab-on-a-chip 151 Langmuir equation 241 lanthanide chelates 253 laser 285, 362 f.

- infrared 117

- nitrogen 21

- ultraviolet 117 leupeptin 191 f. library 89, 231, 308, 329

- NGL127A443 127 ff.

- Optiverse 235

ligand binding domaine (LBD) 390 f. limit of detection (LOD) 190, 200 limit of quantitation (LOQ) 416 f. lipase 287, 292

- phospholipase A2 292 f. Lipinski's rule 95 liposome 238

liquid chromatography 185 f.

12 ff., 22, 32, 41 ff., 54, 126, 166, 177, 207, 230, 255, 307 f.

- two-dimensional (2D-LC) 51 ff., 240 lock spray see dual spray low reactive molecular mass (LRMM)

compounds 22 f. lower limit of quantitation (LLOQ) 267 ff. luciferace yeast pheromone 95 luteolin 243

m magnesium 347 ff. magnetic field strength 36 magnetic sector 5 p38 MAP kinase 388 f. marker 248 ff., 263, 266 f.

- free 255 mass accuracy 381

mass defect 55 mass range 7, 28 f., 55 mass reflectron 33 f. mass resolving power 56

- ultra-high 381 mass spectrum

- negative mode 18, 173 mastoparan 355

- cobalt 21

- a-cyano-4-hydroxycinnamic acid 295

- glycerol 21

matrix assisted laser desorption ionization (MALDI) 12, 20ff., 33 f., 49, 57, 116, 161, 224ff., 239 f., 254, 285 ff., 342, 367

- post source decay (PSD-MALDI) 51

- principle 285 f. matrix effects 43, 411 f. Matthieu's equation 27 maximum entropy algorithm (MaxEnt)

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