Dmso

- synthesis 310 doping control 41 dosing 407

- cassette 407

drug discovery 157 f., 185, 217, 289, 292, 298, 312, 321, 367, 377 ff., 401 f., 413 ff.

- fragment-based 305 ff. drug metabolism 45 ff.

- pharmacokinetic tests (DMPK) 401 ff., 415

drug-protein

- molar ratio 109 ff. drug screening 65

- secondary 89

- - Novartis 94 dual spray 35

duel endothelin receptor antagonist 25 dwell time 44

dynamic background subtraction (DBS) 46 dynamic range 33

EC50 100

-MSEC50 111 ff. EIC see extracted ion current electron impact (EI) ionization 10ff., 56 electrophoresis 50

- two-dimensional 50, 53 electrospray deposition (ESD) 291 electrospray ionization (ESI) 12ff., 22, 38,

42 f., 49, 51, 56, 65 ff., 76 f., 81 ff., 89 ff., 106ff., 123, 137, 161, 164, 186 ff., 200, 203 ff., 224ff., 243, 254, 257 ff., 268, 272, 305 ff., 321 ff., 342, 360, 367, 413 f.

- electrophoretic cell 16

- multi-sprayer (MUX) technology 82 f., 98, 405, 410

- nanoelectrospray 14, 57

- negative mode 18, 91

- positive mode 16, 26, 91 electrostatic mirror see mass reflectron elemental composition 9

ELISA 242 f.

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