Protein Tyrosine Phosphatases as Therapeutic Targets

A. Cheng • N. Uetani • C. Lampron • M. L. Tremblay ())

McGill Cancer Centre and Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Montreal, QC, H3G 1Y6, Canada [email protected]

1 Introduction 192

1.1 Background 192

1.2 PTPs and Impact on Public Health 192

2 Review 193

2.1 PTP Family 193

2.2 Enzyme/Substrate Specificity 194

2.3 Regulation of PTP Action 195

2.4 Involvement of PTP in Human Diseases 197

2.4.1 Metabolic Diseases 197

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