SH2 and PTB domains, as well as protein tyrosine phosphatases, recognize sequences that encompass phosphotyrosine. However, since the latter is hy-drolyzable, peptides that contain this residue serve only as transient antagonists of protein-protein interactions. A number of nonhydrolyzable phosphotyrosine mimetics have been described, in large part due to the effort of Burke and his collaborators at the NIH. Since phosphotyrosine analogs have been the topic of recent reviews, only a cursory discussion of their current status will be presented (Burke et al. 2001; Burke and Lee 2003).
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