List of Contents

Protein Kinase Inhibitors for the Treatment of Disease:

The Promise and the Problems 1

P. Cohen

Part I. General Aspects of PKs Inhibition

New Design Strategies for Ligands That Target Protein Kinase-Mediated

Protein-Protein Interactions 11

D. S. Lawrence

Part II. Pharmacological Potential and Inhibitors of Individual Classes of Protein Kinases

The Paullones: A Family of Pharmacological Inhibitors of Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 47

L. Meijer, M. Leost, O. Lozach, S. Schmitt, C. Kunick

Pharmacological Potential of p38 MAPK Inhibitors 65

Inhibitors of PKA and Related Protein Kinases 85

M. Gaßel, C. Breitenlechner, S. Herrero, R. Engh, D. Bossemeyer

Inhibitors of Protein Kinase CK2: Structural Aspects 125

R. Battistutta, S. Sarno, G. Zanotti

Aminoglycoside Kinases and Antibiotic Resistance 157

Part III. Pharmacological Potential and Inhibitors of Individual Classes of Protein Phosphatases

Protein Tyrosine Phosphatases as Therapeutic Targets 191

Structure-Based Design of Protein Tyrosine Phosphatase Inhibitors 215

N. P. H. M0ller, H. S. Andersen, C. B. Jeppesen, L. F. Iversen

Biological Validation of the CD45 Tyrosine Phosphatase as a Pharmaceutical Target 263

D.R. Alexander

Serine/Threonine Protein Phosphatase Inhibitors with Antitumor Activity .. 295 R.E. Honkanen

Part IV. Inhibitors in Clinical Use or Advanced Clinical Trials

Clinical Immunosuppression using the Calcineurin-Inhibitors Ciclosporin and Tacrolimus 321

Targeted Therapy with Imatinib: An Exception or a Rule? 361

D. Fabbro, G. Fendrich, V. Guez, T. Meyer, P. Furet, J. Mestan, J.D. Griffin, P. W. Manley, S. W. Cowan-Jacob

Clinical Aspects of Imatinib Therapy 391

Isoquinolinesulfonamide: A Specific Inhibitor of Rho-Kinase and the Clinical Aspect of Anti-Rho-Kinase Therapy 411

Discovery and Development of Iressa:

The First in a New Class of Drugs Targeted at the

Epidermal Growth Factor Receptor Tyrosine Kinase 433

A.E. Wakeling

Subject Index 451

HEP (2005) 167:1-7 © Springer-Verlag 2005

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