PK-C inhibition


shown in Table 1, differing sensitivity toward protein kinases may be mainly dependent on the substituent structure. From the standpoint of protein kinases, our previous study (Hagiwara et al. 1987) suggested that the specificity of the PKA-specific inhibitor, H-8 (isoquinolinesulfonamide), for PKA was related closely to the b-subsite of ATP-binding site of PKA.

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