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Human Clinical Trials and Plasma Pharmacokinetics

Because of its spectrum of activity and unique mechanism of action, the Clinical Trials Evaluation Program of the United States National Cancer Institute initiated phase I clinical trials. To determine the pharmacokinetics of fos-triecin, a high-pressure liquid chromatographic method to measure fostriecin in plasma samples was developed (Pillon et al. 1994). Fostriecin is extracted from plasma samples with acetonitrile and then dichloromethane. It is then analyzed by HPLC with a mobile phase of 7.5% acetonitrile in 0.067 M phosphate buffer after separation on a reverse phase C18 column. The extraction efficiency is reported as 70% and the sensitivity limit 100 ng/ml.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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