Other PTPs in Infectious Diseases

Leishmania donovani (Ld) is an intracellular protozoan parasite that is the causative agent of visceral leishmaniasis. Recent findings suggest that the capacity of Ld to suppress host immune responses such as macrophage phagocytosis is related to SHP-1 (Blanchette et al. 1999; Nandan et al. 2002). It has also been suggested that calpain-mediated cleavage and activation of host cell PTP1B may play a role in amebiasis caused by the protozoan Entamoeba histolytica (Teixeira and Mann 2002). It is well known that the transcription and replication of HIV-1 (human immunodeficiency virus 1), the causal agent of acquired immunodeficiency syndrome (AIDS), is linked to T cell activation. Interestingly, SHP-1 may act as an important host factor participating in HIV-1 long terminal repeat (LTR) transactivation (Fortin et al. 2001; Quellet et al. 2003).

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