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Yersinia pestis

Yersinia pestis presents historical value as being responsible for the Black Plague (Fallman et al. 2002). This pathogen expresses the phosphatase YopH that contributes to block macrophage phagocytosis and slow down the onset of the inflammatory response, thus favoring pathogen survival. The activity of YopH is essential for this effect, and it suggests that dephosphorylation of host proteins participates in this mechanism. These substrates include p130Cas and Fyn binding protein. Recently, aurintricarboxylic acid has been shown as a selective YopH inhibitor, and it may be therapeutically useful (Liang et al. 2003).

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