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ROCK (Rho-dependent protein kinase) 1

roscovitine 55 rotamer

- change 108

- conformation 88 rub oxistaurin 116 RWJ65657 71

salmonellosis 205 Sandimmun 332 sarcoma 369 SB 203580 55, 68

SCID (severe combined immunodeficiency disease) 203, 266 second

- aryl phosphate binding site 226

- binding site 98 selectivity 134

- determining regions 223, 245

- over TC-PTP 249 Sem5 28 seminoma 403

severe combined immunodeficiency disease (SCID) 203 SH2 domain 19 SH3 domain 19

signal transducers and activators of transcription (STATs) 273 sirolimus 328 SKAP-55 272 spastic artery 426 sphingolipid analogue 110 spindle 301

squamous cell carcinoma of the head and neck (SCCHN) 441 Src 17

- family of tyrosine kinases 269

- homology 2 195 STAT3 440

staurosporine 55, 104, 106, 108, 133 steric conflict 96, 115 STI571 134, 363, 365 Streptomyces

- tsukubaensis 327 streptomycin 158 structure-activity relationship 236

subarachnoid hemorrhage 422 s. recognition 131 s. specificity 194 sulfonamide derivative 412 sulphenyl-amide 228 supramolecular activation cluster

(SMAC) 270 Syk tyrosine kinase 273 symptomatic spasm 427 synthetic scaffold 245

T cell

- activation cascade 325

- antigen receptor (TCR) 265

- proliferation 328 TAB1 68

tacrolimus (FK506) 327, 335, 337 tamoxifen 435

tandem phosphorylated pTyr IR 248 TBB (tetrabromo-2-azabenzimidazole) 145

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