Many studies have examined the role of transferring patients from ci-closporin to tacrolimus as 'rescue therapy' for acute rejection that is refractory to conventional therapy. Unfortunately, the nature of the study populations and the clinical situation has precluded the use of randomised studies. Therefore, the data from such studies have been anecdotal and uncontrolled. Nevertheless there are data to support the view that switching from ci-closporin to tacrolimus can be a beneficial part of the treatment for refractory rejection (Woodle et al. 1996; Mentzer et al. 1998).
Was this article helpful?