PTPs and Impact on Public Health
In the last 5 years, the PTP field has rapidly gained special interest with particular emphasis on PTP1B. Gene targeting studies in mice strongly supported that PTP1B is involved in the insulin resistance associated with type 2 diabetes mellitus (Elchebly et al. 1999a; Klaman et al. 2000a). This disease and associated disorders are becoming a serious threat to human health with a global figure of about 150 million people affected. Moreover, mutations in genes coding for different members of the PTP family have been associated with various congenital diseases (Minassian et al. 1998; Serratosa et al. 1999; Digilio et al. 2002; Legius et al. 2002; Tartaglia et al. 2002). Overexpression of several PTPs has also been observed in several human cancers, including breast and colon cancers (Tabiti et al. 1995; Lee et al. 2000; Pestell et al. 2000; Saha et al. 2001). These observations together indicate that PTPs are key factors of many different diseases with a wide impact on public health. PTPs are also critical factors for several pathogens that cause a large spectrum of diseases worldwide, amongst which typhoid fever is still responsible for 600,000 deaths annually (Pang et al. 1998) and Helicobacter pylori, which is responsible for gastric ulcer and malignancy, infects about half of the world population (Rothenbacher and Brenner 2003). Thus, selected PTPs may also represent novel targets against particular infectious diseases. In this review, we will describe the recent findings demonstrating the implication of PTPs in human diseases and health care. We will also discuss the therapeutic potential of targeting various members of the PTP family.
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All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.