CD45 and Macrophages
CD45_/_ macrophages display abnormally high integrin receptor-mediated adherence compared with wild-type controls, correlating with the matura tion of fewer bone marrow-derived macrophages when differentiated in vitro (Roach et al. 1997). Therefore in contrast to the situation with antigen receptors, CD45 appears to exert a predominantly negative effect on integrin signalling. Consistent with this observation, in a CD45-deficient T cell line, enhanced adhesion to fibronectin via the a501 (VLA-5) integrin but not via a4bi (VLA-4) has been noted (Shenoi et al. 1999).
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