CD45 and Mast Cells

Investigation of mast cell function in CD45 exon 6 targeted mice has suggested that CD45 is essential for degranulation triggered via the high-affinity immunoglobulin E receptor (Fc-eR1) (Berger et al. 1994). Similar results have been obtained using CD45-deficient cell lines (Zhang and Siraganian 1999; Murakami et al. 2000). On the other hand, stimulation of the Fc-eR1 receptor in mast cells from either exon 9-targeted (N. Holmes, unpublished results) or exon 12-targeted (V. Tybulewicz, unpublished results) mice has not revealed any obvious defect in primary mast cell degranulation when CD45 is completely absent. Therefore the precise role of CD45 in Fc-eR1 signal transduction remains to be clearly resolved.

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