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Specific Toxicity

Although the calcineurin-inhibitors are potent immunosuppressive agents, their clinical use is limited by their toxicity. The commonest serious and dose-limiting problem is nephrotoxicity. A large number of other side effects can also occur. There are some differences between the toxicity of ci-closporin and tacrolimus (Table 2).

Table 2 Comparison of the toxicity of ciclosporin and tacrolimus

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