Cd28 269

CD3 monoclonal antibody 266 CD45 195,203

- CD45-deficient mice 267

- inhibitor 266

- isoforms 274

- phosphotyrosine phosphatase 264

- RB 275 cdc2 22 CDC25 192, 199 CDK1 51 CDK2 4, 129 CDK5 28, 58 centrosome 301 cerebral

- artery 428

- ischemia 428

- animal models 425

- vasospasm 422 cetuximab 442 chronic

- myeloid leukemia (CML) 2, 392

- - lymphoid blast crisis 395

- myelomonocytic leukemia 367 ciclosporin 327, 331, 337

CK2 (casein kinase 2) 126

- three-dimensional structure 131 CKI-7 179

c-Kit 372, 377 clinical trial 309 -phase III 116 co-crystallization 108, 140

- structures 112 COL1A1 404 colitis 336

combinatorial library method 11 COMPARE 53

conformational change 115, 167 consensus sequence 12, 107 conserved lysine 89 constitutive activity 127 contractile response 412 Coomb's test 340 corticosteroid 333 COX-2 73

coxsackievirus B3 (CVB3) 274 Crk 29 CSK 23 C-terminal

- lobe 375

cyclic adenosine monophosphate (cAMP)

87 cyclin

- cyclin-dependent kinase 47 cyclophilin 329

cyclosporin (see also ciclosporin) 1, 5 Cylindrocarpon lucidum 327 cytochrome P450 344 cytogenetic response 396, 397

DARPP-32 58 2-deoxystreptamine 159 dermatofibrosarcoma protuberans

(DFSP) 369 dermatological disorder 335 DFG-out conformation 91 diabetes mellitus 192, 342

- type 2 192 diacylglycerol 109

- pathway 329

difluoromethylenephosphonic (DFMP)

group 243 drug

- interaction 343

- structure-based design 150, 223

- target 251 dyslipidaemia 242

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Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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