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Interstitial Nephritis

Chronic toxicity is associated with structural changes in the kidney. In native kidneys there is global and segmental glomerular sclerosis. Surviving glomeruli tend to be larger, indicating hyperfiltration, and proteinuria is common Myers et al. 1988 Bertani et al. 1991 . The changes are believed to be secondary to afferent arteriolar vasculopathy leading to glomerular isch-aemia and tubular atrophy. The tubular atrophy and fibrosis follow a striped pattern which begins in the medullar and...

References

Al-Ali HK, Lange T, Krahl R, Mueller C, Patzer G, Niederwieser D, Deininger MWN 2002 BCR-ABL kinase domain mutations in patients with secondary but not primary resistance to imatinib. Blood 100 Suppl 368a Apperley JF, Gardembas M, Melo JV, Russell-Jones R, Bain BJ, Baxter EJ, Chase A, Chessells JM, Colombat M, Dearden CE, Dimitrijevic S, Mahon FX, Marin D, Nikolo-va Z, Olavarria E, Silberman S, Schultheis B, Cross NC, Goldman JM 2002 Response to imatinib mesylate in patients with chronic...

Ptp1b

Undeniably, PTP1B has been the most studied PTP to date as judged by the recent numerous publications and its potential impact in the diabetes field. The intense focus on PTP1B is primarily based on the observation that PTP1B is a negative regulator of insulin and leptin signal transduction Cheng et al. 2002a Cook and Unger 2002 . Indeed, PTP1B-deficient mice display both increased insulin Elchebly et al. 1999a Klaman et al. 2000b and leptin signaling Cheng et al. 2002b Zabolotny et al. 2002 ....