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Hypertension is common after all forms of organ transplantation and this is related to the use of CNIs. The mechanisms linking the CNIs to hypertension are not fully understood but, as previously described, they interfere with vascular control mechanisms and increase activity of the sympathetic nervous system. In addition, the nephrotoxicity caused by these drugs may play a role in the development of hypertension (Andoh et al. 2001 Johnson et al. 2002). Interestingly, tacrolimus appears to be...

Rationale

The application of molecular genetic techniques to cancer biology has elucidated multiple, interacting biochemical pathways involved in the malignant transformation and unrestricted growth of epithelial cells from which the majority of human solid tumours originate (Hunter 1997 Blume-Jensen and Hunter 2001). The first complete description of a biochemical pathway originating at the cell surface, propagating signals from the tumour cell environment and leading to changes in gene transcription...

References

Al-Ali HK, Lange T, Krahl R, Mueller C, Patzer G, Niederwieser D, Deininger MWN 2002 BCR-ABL kinase domain mutations in patients with secondary but not primary resistance to imatinib. Blood 100 Suppl 368a Apperley JF, Gardembas M, Melo JV, Russell-Jones R, Bain BJ, Baxter EJ, Chase A, Chessells JM, Colombat M, Dearden CE, Dimitrijevic S, Mahon FX, Marin D, Nikolo-va Z, Olavarria E, Silberman S, Schultheis B, Cross NC, Goldman JM 2002 Response to imatinib mesylate in patients with chronic...

Ptp1b

Undeniably, PTP1B has been the most studied PTP to date as judged by the recent numerous publications and its potential impact in the diabetes field. The intense focus on PTP1B is primarily based on the observation that PTP1B is a negative regulator of insulin and leptin signal transduction Cheng et al. 2002a Cook and Unger 2002 . Indeed, PTP1B-deficient mice display both increased insulin Elchebly et al. 1999a Klaman et al. 2000b and leptin signaling Cheng et al. 2002b Zabolotny et al. 2002 ....