Aguet M (1980) High-affinity binding of 125I-labelled mouse interferon to a specific cell surface receptor. Nature 284:459-461 Aguet M, Mogensen KE (1983) Interferon receptors. Interferon 5:1-22

Basu L, Yang CH, Murti A, Garcia JV, Croze E, Constantinescu SN, Mullersman JE, Pfeffer LM (1998) The antiviral action of interferon is potentiated by removal of the conserved IRTAM domain of the IFNAR1 chain of the interferon alpha/beta receptor: effects on JAK-STAT activation and receptor down-regulation. Virology 242:14-21

Boggon TJ, Li Y, Manley PW, Eck MJ (2005) Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog. Blood 106:996-1002 Branca AA (1988) Interferon receptors. In Vitro Cell Dev Biol 24:155-165 Brierley MM, Fish EN (2002) Review: IFN-alpha/beta receptor interactions to biologic outcomes: understanding the circuitry. J Interferon Cytokine Res 22:835-845 Brierley MM, Fish EN (2005) Stats: multifaceted regulators of transcription. J Interferon

Cytokine Res 25:733-744 Cajean-Feroldi C, Nosal F, Nardeux PC, Gallet X, Guymarho J, Baychelier F, Sempe P, Tovey MG, Escary JL, Eid P (2004) Identification of residues of the IFNAR1 chain of the type I human interferon receptor critical for ligand binding and biological activity. Biochemistry 43:12498-12512 Chill JH, Quadt SR, Levy R, Schreiber G, Anglister J (2003) The human type I interferon receptor: NMR structure reveals the molecular basis of ligand binding. Structure 11:791-802

Chuntharapai A, Gibbs V, Lu J, Ow A, Marsters S, Ashkenazi A, De Vos A, Jin Kim K (1999) Determination of residues involved in ligand binding and signal transmission in the human IFN-alpha receptor 2. J Immunol 163:766-773 Coelho LF, de Freitas Almeida GM, Mennechet FJ, Blangy A, Uze G (2005) Interferon-{alpha} and -{beta} differentially regulate osteoclastogenesis: role of differential induction of chemokine CXCL11 expression. Proc Natl Acad Sci U S A 102:1191711922

Cohen B, Novick D, Barak S, Rubinstein M (1995) Ligand-induced association of the type I interferon receptor components. Mol Cell Biol 15:4208-4214 Cull VS, Tilbrook PA, Bartlett EJ, Brekalo NL, James CM (2003) Type I interferon differential therapy for erythroleukemia: specificity of STAT activation. Blood 101:2727-2735 Cunningham BC, Wells JA (1993) Comparison of a structural and a functional epitope.

J Mol Biol 234:554-563 Cutrone EC, Langer JA (1997) Contributions of cloned type I interferon receptor sub-

units to differential ligand binding. FEBS Lett 404:197-202 Cutrone EC, Langer JA (2001) Identification of critical residues in bovine IFNAR-1

responsible for interferon binding. J Biol Chem 276:17140-17148 Darnell JE Jr (1997) STATs and gene regulation. Science 277:1630-1635 Darnell JE Jr, Kerr IM, Stark GR (1994) Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415-1421

Domanski P, Witte M, Kellum M, Rubinstein M, Hackett R, Pitha P, Colamonici OR (1995) Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling. J Biol Chem 270:21606-21611

Domanski P, Fish E, Nadeau OW, Witte M, Platanias LC, Yan H, Krolewski J, Pitha P, Colamonici OR (1997) A region of the beta subunit of the interferon alpha receptor different from box 1 interacts with Jakl and is sufficient to activate the Jak-Stat pathway and induce an antiviral state. J Biol Chem 272:26388-26393 Dondi E, Pattyn E, Lutfalla G, Van Ostade X, Uze G, Pellegrini S, Tavernier J (2001) Down-modulation of type 1 interferon responses by receptor cross- competition for a shared Jak kinase. J Biol Chem 276:47004-47012 Dunn GP, Bruce AT, Sheehan KC, Shankaran V, Uppaluri R, Bui JD, Diamond MS, Koebel CM, Arthur C, White JM, Schreiber RD (2005) A critical function for type I interferons in cancer immunoediting. Nat Immunol 6:722-729 Fish EN (1992) Definition of receptor binding domains in interferon-alpha. J Interferon Res 12:257-266

Foster GR, Masri SH, David R, Jones M, Datta A, Lombardi G, Runkell L, de Dios C, Sizing I, James MJ, Marelli-Berg FM (2004) IFN-alpha subtypes differentially affect human T cell motility. J Immunol 173:1663-1670 Fuchs SY, Chen A, Xiong Y, Pan ZQ, Ronai Z (1999) HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phos-phorylation-dependent degradation of IkappaB and beta-catenin. Oncogene 18:2039-2046

Gauzzi MC, Velazquez L, McKendry R, Mogensen KE, Fellous M, Pellegrini S (1996) Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase. J Biol Chem 271:20494-20500 Gauzzi MC, Barbieri G, Richter MF, Uze G, Ling L, Fellous M, Pellegrini S (1997) The amino-terminal region of Tyk2 sustains the level of interferon alpha receptor 1, a component of the interferon alpha/beta receptor. Proc Natl Acad Sci U S A 94:1183911844

Gavutis M, Lata S, Lamken P, Muller P, Piehler J (2005) Lateral ligand-receptor interactions on membranes probed by simultaneous fluorescence-interference detection. Biophys J 88:4289-4302 Gavutis M, Jaks E, Lamken P, Piehler J (2006) Determination of the two-dimensional interaction rate constants of a cytokine receptor complex. Biophys J 90:3345-3355 Gibbs VC, Takahashi M, Aguet M, Chuntharapai A (1996) A negative regulatory region in the intracellular domain of the human interferon-alpha receptor. J Biol Chem 271:28710-28716

Goldman JM (2005) A unifying mutation in chronic myeloproliferative disorders.

N Engl J Med 352:1744-1746 Gresser I, Bandu MT, Brouty-Boye D (1974) Interferon and cell division. IX. Interferon-

resistant L1210 cells: characteristics and origin. J Natl Cancer Inst 52:553-559 Harlos K, Martin DM, O'Brien DP, Jones EY, Stuart DI, Polikarpov I, Miller A, Tudden-ham EG, Boys CW (1994) Crystal structure of the extracellular region of human tissue factor. Nature 370:662-666 Hilkens CM, Schlaak JF, Kerr IM (2003) Differential responses to IFN-alpha subtypes in human T cells and dendritic cells. J Immunol 171:5255-5263

Hu R, Bekisz J, Hayes M, Audet S, Beeler J, Petricoin E, Zoon K (1999) Divergence of binding, signaling, and biological responses to recombinant human hybrid IFN. J Immunol 163:854-860 Hu R, Bekisz J, Schmeisser H, McPhie P, Zoon K (2001) Human IFN-alpha protein engineering: the amino acid residues at positions 86 and 90 are important for antiproliferative activity. J Immunol 167:1482-1489 Huang LJ, Constantinescu SN, Lodish HF (2001) The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor. Mol Cell 8:1327-1338 Isaacs A, Lindenmann J (1957) Virus interference. I. The interferon. Proc R Soc Lond B Biol Sci 147:258-267

Jaitin DA, Roisman LC, Jaks E, Gavutis M, Piehler J, Van der Heyden J, Uze G, Schreiber G (2006) Inquiring into the differential action of interferons (IFNs): an IFN-alpha2 mutant with enhanced affinity to IFNAR1 is functionally similar to IFN-beta. Mol Cell Biol 26:1888-1897 Karpusas M, Nolte M, Benton CB, Meier W, Lipscomb WN, Goelz S (1997) The crystal structure of human interferon beta at 2.2-A resolution. Proc Natl Acad Sci U S A 94:11813-11818

Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW (2002) Signaling through the

JAK/STAT pathway, recent advances and future challenges. Gene 285:1-24 Klaus W, Gsell B, Labhardt AM, Wipf B, Senn H (1997) The three-dimensional high resolution structure of human interferon alpha-2a determined by heteronuclear NMR spectroscopy in solution. J Mol Biol 274:661-675 Kotenko SV, Langer JA (2004) Full house: 12 receptors for 27 cytokines. Int Immuno-pharmacol 4:593-608

Kotenko SV, Pestka S (2000) Jak-Stat signal transduction pathway through the eyes of cytokine class II receptor complexes. Oncogene 19:2557-2565 Kotenko SV, Gallagher G, Baurin VV, Lewis-Antes A, Shen M, Shah NK, Langer JA, Sheikh F, Dickensheets H, Donnelly RP (2003) IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. Nat Immunol 4:69-77 Krause CD, Pestka S (2005) Evolution of the class 2 cytokines and receptors, and discovery of new friends and relatives. Pharmacol Ther 106:299-346 Kumar KG, Tang W, Ravindranath AK, Clark WA, Croze E, Fuchs SY (2003) SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferonalpha receptor. EMBO J 22:5480-5490 Kumar KG, Krolewski JJ, Fuchs SY (2004) Phosphorylation and specific ubiquitin acceptor sites are required for ubiquitination and degradation of the IFNAR1 subunit of type I interferon receptor. J Biol Chem 279:46614-46620 Lamken P, Lata S, Gavutis M, Piehler J (2004) Ligand-induced assembling of the type I

interferon receptor on supported lipid bilayers. J Mol Biol 341:303-318 Lamken P, Gavutis M, Peters I, Van der Heyden J, Uze G, Piehler J (2005) Functional cartography of the ectodomain of the type I interferon receptor subunit ifnar 1. J Mol Biol 350:476-488 Langer JA, Yang J, Carmillo P, Ling LE (1998) Bovine type I interferon receptor protein BoIFNAR-1 has high-affinity and broad specificity for human type I interferons. FEBS Lett 421:131-135

Leaman DW, Chawla-Sarkar M, Jacobs B, Vyas K, Sun Y, Özdemir A, Yi T, Williams BR, Borden EC (2003) Novel growth and death related interferon-stimulated genes (ISGs) in melanoma: greater potency of IFN-beta compared with IFN-alpha2. J Interferon Cytokine Res 23:745-756 Lewerenz M, Mogensen KE, Uze G (1998) Shared receptor components but distinct complexes for alpha and beta interferons. J Mol Biol 282:585-599 Lindauer K, Loerting T, Liedl KR, Kroemer RT (2001) Prediction of the structure of human Janus kinase 2 (JAK2) comprising the two carboxy-terminal domains reveals a mechanism for autoregulation. Protein Eng 14:27-37 Lucet IS, Fantino E, Styles M, Bamert R, Patel Ö, Broughton SE, Walter M, Burns CJ, Treutlein H, Wilks AF, Rossjohn J (2006) The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor. Blood 107:176-183 Lutfalla G, Uze G (1994) Structure of the murine interferon alpha/beta receptor-encoding gene: high-frequency rearrangements in the interferon-resistant L1210 cell line. Gene 148:343-346 Lutfalla G, Holland SJ, Cinato E, Monneron D, Reboul J, Rogers NC, Smith JM, Stark GR, Gardiner K, Mogensen KE, Kerr IM, Uze G (1995) Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster. EMBO J 14:5100-5108 Malakhova OA, Kim KI, Luo JK, Zou W, Kumar KG, Fuchs SY, Shuai K, Zhang DE (2006) UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity. EMBO J 25:2358-2367 Marijanovic Z, Ragimbeau J, Kumar KG, Fuchs SY, Pellegrini S (2006) TYK2 activity promotes ligand-induced IFNAR1 proteolysis. Biochem J 397:31-38 Miaczynska M, Pelkmans L, Zerial M (2004) Not just a sink: endosomes in control of signal transduction. Curr Opin Cell Biol 16:400-406 Mitsui Y, Senda T, Shimazu T, Matsuda S, Utsumi J (1993) Structural, functional and evolutionary implications of the three-dimensional crystal structure of murine interferon-beta. Pharmacol Ther 58:93-132 Mogensen KE, Uze G, Eid P (1989) The cellular receptor of the alpha-beta interferons.

Experientia 45:500-508 Mogensen KE, Lewerenz M, Reboul J, Lutfalla G, Uze G (1999) The type I interferon receptor: structure, function, and evolution of a family business. J Interferon Cytokine Res 19:1069-1098 Novick D, Cohen B, Rubinstein M (1994) The human interferon alpha/beta receptor:

characterization and molecular cloning. Cell 77:391-400 Ortaldo JR, Herberman RB, Harvey C, Osheroff P, Pan YC, Kelder B, Pestka S (1984) A species of human alpha interferon that lacks the ability to boost human natural killer activity. Proc Natl Acad Sci U S A 81:4926-4929 Peleg-Shulman T, Roisman LC, Zupkovitz G, Schreiber G (2004) Optimizing the binding affinity of a carrier protein: a case study on the interaction between soluble ifnar2 and interferon beta. J Biol Chem 279:18046-18053 Pellegrini S, John J, Shearer M, Kerr IM, Stark GR (1989) Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway. Mol Cell Biol 9:4605-4612 Pestka S (1997) The interferon receptors. Semin Oncol 24:S9-S40

Pestka S, Krause CD, Walter MR (2004) Interferons, interferon-like cytokines, and their receptors. Immunol Rev 202:8-32 Piehler J, Schreiber G (1999) Mutational and structural analysis of the binding interface between type I interferons and their receptor Ifnar2. J Mol Biol 294:223-237 Piehler J, Roisman LC, Schreiber G (2000) New structural and functional aspects of the type I interferon-receptor interaction revealed by comprehensive mutational analysis of the binding interface. J Biol Chem 275:40425-40433 Platanias LC (2005) Mechanisms of type-I- and type-II-interferon-mediated signalling.

Nat Rev Immunol 5:375-386 Platanias LC, Uddin S, Domanski P, Colamonici OR (1996) Differences in interferon alpha and beta signaling. Interferon beta selectively induces the interaction of the alpha and betaL subunits of the type I interferon receptor. J Biol Chem 271:23630-23633 Polo S, Di Fiore PP (2006) Endocytosis conducts the cell signaling orchestra. Cell 124:897-900

Radhakrishnan R, Walter LJ, Hruza A, Reichert P, Trotta PP, Nagabhushan TL, Walter MR (1996) Zinc mediated dimer of human interferon-alpha 2b revealed by x-ray crystallography. Structure 4:1453-1463 Radtke S, Hermanns HM, Haan C, Schmitz-Van De Leur H, Gascan H, Heinrich PC, Behrmann I (2002) Novel role of Janus kinase 1 in the regulation of oncostatin M receptor surface expression. J Biol Chem 277:11297-11305 Ragimbeau J, Dondi E, Alcover A, Eid P, Uze G, Pellegrini S (2003) The tyrosine kinase

Tyk2 controls IFNAR1 cell surface expression. EMBO J 22:537-547 Rani MR, Foster GR, Leung S, Leaman D, Stark GR, Ransohoff RM (1996) Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha. J Biol Chem 271:22878-22884 Rani MR, Hibbert L, Sizemore N, Stark GR, Ransohoff RM (2002) Requirement of phosphoinositide 3-kinase and Akt for interferon-beta-mediated induction of the beta-R1 (SCYB11) gene. J Biol Chem 277:38456-38461 Richter MF, Dumenil G, Uze G, Fellous M, Pellegrini S (1998) Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1. J Biol Chem 273:24723-24729 Roisman LC, Piehler J, Trosset JY, Scheraga HA, Schreiber G (2001) Structure of the interferon-receptor complex determined by distance constraints from doublemutant cycles and flexible docking. Proc Natl Acad Sci U S A 98:13231-13236 Roisman LC, Jaitin DA, Baker DP, Schreiber G (2005) Mutational analysis of the IFNAR1 binding site on IFNalpha2 reveals the architecture of a weak ligand-receptor binding-site. J Mol Biol 353:271-281 Runkel L, Pfeffer L, Lewerenz M, Monneron D, Yang CH, Murti A, Pellegrini S, Goelz S, Uze G, Mogensen K (1998) Differences in activity between alpha and beta type I interferons explored by mutational analysis. J Biol Chem 273:8003-8008 Runkel L, deDios C, Karpusas M, Betzenhauser M, Muldowney C, Zafari M, Benjamin CD, Miller S, Hochman PS, Whitty A (2000) Systematic mutational mapping of sites on human interferon-beta-1a that are important for receptor binding and functional activity. Biochemistry 39:2538-2551 Saleh AZ, Fang AT, Arch AE, Neupane D, El Fiky A, Krolewski JJ (2004) Regulated proteolysis of the IFNaR2 subunit of the interferon-alpha receptor. Oncogene 23:7076-7086

Senda T, Shimazu T, Matsuda S, Kawano G, Shimizu H, Nakamura KT, Mitsui Y (1992) Three-dimensional crystal structure of recombinant murine interferon-beta. EMBO J 11:3193-3201 Severa M, Remoli ME, Giacomini E, Ragimbeau J, Lande R, Uze G, Pellegrini S, Coccia EM (2006) Differential responsiveness to IFN-alpha and IFN-beta ofhuman mature DC through modulation of IFNAR expression. J Leukoc Biol 79:1286-1294 Slate DL, Ruddle FH, Tan YH (1981) Genetic control of the interferon system. Interferon 3:65-76

Slutzki M, Jaitin DA, Ben Yehezkel T, Schreiber G (2006) Variations in the unstructured C-terminal tail of interferons contribute to differential receptor binding and biological activity. J Mol Biol 360:1010-1030 Sorkin A, Von Zastrow M (2002) Signal transduction and endocytosis: close encounters of many kinds. Nat Rev Mol Cell Biol 3:600-614 Stark GR, Kerr IM, Williams BR, Silverman RH, Schreiber RD (1998) How cells respond to interferons. Annu Rev Biochem 67:227-264 Stewart WE II (1979) The interferon system. Springer, Vienna New York Takayanagi H, Sato K, Takaoka A, Taniguchi T (2005) Interplay between interferon and other cytokine systems in bone metabolism. Immunol Rev 208:181-193 Tough DF (2004) Type I interferon as a link between innate and adaptive immunity through dendritic cell stimulation. Leuk Lymphoma 45:257-264 Usacheva A, Sandoval R, Domanski P, Kotenko SV, Nelms K, Goldsmith MA, Colamonici OR (2002) Contribution of the box 1 and box 2 motifs of cytokine receptors to Jak1 association and activation. J Biol Chem 277:48220-48226 Uze G, Lutfalla G, Gresser I (1990) Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA. Cell 60:225-234 Uze G, Lutfalla G, Bandu MT, Proudhon D, Mogensen KE (1992) Behavior of a cloned murine interferon alpha/beta receptor expressed in homospecific or heterospecific background. Proc Natl Acad Sci U S A 89:4774-4778 Uze G, Di Marco S, Mouchel-Vielh E, Monneron D, Bandu MT, Horisberger MA, Dorques A, Lutfalla G, Mogensen KE (1994) Domains of interaction between alpha interferon and its receptor components. J Mol Biol 243:245-257 Vitale G, de Herder WW, van Koetsveld PM, Waaijers M, Schoordijk W, Croze E, Colao A, Lamberts SW, Hofland LJ (2006) IFN-beta is a highly potent inhibitor of gastroen-teropancreatic neuroendocrine tumor cell growth in vitro. Cancer Res 66:554-562 Walter MR (2004) Structural analysis of IL-10 and type I interferon family members and their complexes with receptor. Adv Protein Chem 68:171-223 Walter MR, Windsor WT, Nagabhushan TL, Lundell DJ, Lunn CA, Zauodny PJ, Narula SK (1995) Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor. Nature 376:230-235 Weissmann C, Weber H (1986) The interferon genes. Prog Nucleic Acid Res Mol Biol 33:251-300

Wheelock EF (1965) Interferon-like virus-inhibitor induced in human leukocytes by phytohemagglutinin. Science 149:310-311

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