Phenoxybenzamine is presented for historical perspective; it no longer indicated in clinical treatment of BPH. A long-acting, nonselective a-blocker with affinity for both a1- and a2-receptors, its current indication is for treatment of hypertension and sweating associated with pheochromocytoma. Demonstrable pharmacologic effects may persist for 3-4 d after intravenous administration (19).

Early studies of phenoxybenzamine demonstrated therapeutic effect in patients with BPH-associated voiding symptoms. In two large reviews, 80-90% of treated patients reported symptomatic improvement (20,21). Maximum urinary flow rate improvements were noted as well. Significant adverse effects occurred in approx 30% of treated

Table 1

Summary of a-Antagonists in Current Clinical Use for the Treatment of Male LUTS





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Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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