Phenoxybenzamine is presented for historical perspective; it no longer indicated in clinical treatment of BPH. A long-acting, nonselective a-blocker with affinity for both a1- and a2-receptors, its current indication is for treatment of hypertension and sweating associated with pheochromocytoma. Demonstrable pharmacologic effects may persist for 3-4 d after intravenous administration (19).

Early studies of phenoxybenzamine demonstrated therapeutic effect in patients with BPH-associated voiding symptoms. In two large reviews, 80-90% of treated patients reported symptomatic improvement (20,21). Maximum urinary flow rate improvements were noted as well. Significant adverse effects occurred in approx 30% of treated

Table 1

Summary of a-Antagonists in Current Clinical Use for the Treatment of Male LUTS





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