Affected Organs And Cell Types In Polyomavirusassociated Disease And Persistent Virus Infection

The two human polyomaviruses BKV and JCV are associated with persistent infection and diseases of the urogenital tract and the central nervous system (CNS). Induction of disease by the viruses is regularly linked to states of im-munoincompetence. The most prominent underlying complications are AIDS and lymphoproliferative disorders. Moreover, iatrogenic immunosuppression in the course of transplantation or therapy of autoimmune disorders can contribute to polyomavirus-induced disease....

Human Cancer

Until recently, evidence for the involvement of JCV, BKV, and SV40 in human cancer was virtually nonexistent. The advent of polymerase chain reaction (PCR) technology, however, has sparked renewed interest in the issue and provided provocative evidence that these viruses may indeed play a role in certain neoplasms. The fact that these viruses can indeed cause tumors is not disputed, based on the in vitro studies described above as well as experiments in animals. For example, SV40 induces...

References

Agostini HT, Jobes DV, Chima SC, Ryschkewitsch CF, Stoner GL 1999 Natural and pathogenic variation in the JC virus genome. Recent Res Dev Virol 1 683-701. Agostini HT, Ryschkewitsch CF, Mory R, Singer EJ, Stoner GL 1997 JC virus JCV genotypes in brain tissue from patients with progressive multifocal leukoencepha-lopathy PML and in urine from controls without PML Increased frequency of JCV Type 2 in PML. J Infect Dis 176 1-8. Ahmed S, Chowdhury M, Khalili K 1990a Regulation of a human...

William J. Hadlow Montana

Carleton Gajdusek

Sam Chou and myself with our poster exhibit ''Polyoma-like Virions in a Human Demyelinating Disease'' at the annual meeting of the American Academy of Neurology, in Philadelphia, in 1966. Figure 2.3. Dr. Sam Chou and myself with our poster exhibit ''Polyoma-like Virions in a Human Demyelinating Disease'' at the annual meeting of the American Academy of Neurology, in Philadelphia, in 1966. The first European recognition came from Dr. W. Bernhard, Director of the Cancer Research...

Cellular Receptors For Sv40 Introduction

SV40 was initially isolated from cultures of rhesus monkey kidney cells being used to propagate vaccine strains of poliovirus Sweet and Hilleman, 1960 . At the time of its isolation, several million individuals had received poliovirus vaccines contaminated with significant amounts of this oncogenic virus Shah and Nathanson, 1976 . Fortunately, epidemiologic studies do not show increased rates of cancer among the inoculated individuals Shah, 2000 . However, recent studies suggest that SV40 may...