We saw above that the release of hormones can be under feedback control, usually negative feedback control. Similarly, the abundance of receptors for a hormone can be under feedback control. In some cases, continuous high levels of a hormone can decrease the number of its receptors, a process known as downregulation. Upregulation of receptors, or an increase in their abundance, is a positive feedback mechanism, and is less common.
An example of downregulation is type II diabetes mellitus, which is characterized by elevated levels of circulating insulin, but a loss of insulin receptors. Although genetic factors are likely to be involved, a possible immediate cause of the disease is an overstimulation of pancreatic release of insulin by excessive carbohydrate intake, which leads to downregulation of the insulin receptors.
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All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.