7.9 The Citric Acid Cycle Releases Much More Free Energy Than Glycolysis Does
Electron carriers (NAD in glycolysis; NAD and FAD in the citric acid cycle) are reduced and ATP is generated in reactions coupled to other reactions, producing major drops in free energy as metabolism proceeds.
goal of oxidizing two acetyl groups to two molecules of
CO2?" There are three reasons:
► First, the cycle includes molecules that have other roles in the cell. As we will see later in this chapter, the intermediates of the citric acid cycle are themselves catabolic (breakdown) products or anabolic (synthesis) building blocks of other molecules, such as amino acids and nucleotides.
► Second, the citric acid cycle is far more efficient at harvesting energy from acetyl CoA than any single reaction could be.
► Third, evolution is a conservative, add-on process. It rarely operates by inventing an entirely new process.
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