Genes can be inactivated by homologous recombination

As we have seen, artificial mutations provide an excellent way of asking "What if" questions about the role of a gene in cell function. Homologous recombination can be used to ask these questions at the organism level. The aim of this tech tttt tttt tttt cDNA

Targeted gene

Vector (plasmid)

Targeted gene

Vector (plasmid)

Dna Recombination Questions

Recombination occurs. The inactivated gene is now in the mouse genome, and the vector is lost during cell division.

Inactivated mouse gene

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