How Would You Test The Dna Of The Older Brother To Determine Whether He Is A Carrier For Cystic Fibrosis

1. How do oncogenes and tumor suppressor genes and their functions change in tumor cells? Propose targets for cancer therapy involving these gene products.

2. In the past, it was common for people with phenylketonuria (PKU) who were placed on a low-phenylalanine diet after birth to be allowed to return to a normal diet during their teenage years. Although the levels of phenylalanine in their blood were high, their brains were thought to be beyond the stage of being harmed. If a woman with PKU becomes pregnant, however, a problem arises. Typically, the fetus is heterozygous but is unable at early stages of development to metabolize the high levels of phenylalanine that arrive from the mother's blood. Why is the fetus heterozygous? What do you think would happen to the fetus during this "maternal PKU" situation? What would be your advice to a woman with PKU who wants to have a child?

3. Cystic fibrosis is an autosomal recessive disease in which thick mucus is produced in the lungs and airways. The gene responsible for this disease codes for a protein composed of 1,480 amino acids. In most patients with cystic fibrosis, the protein has 1,479 amino acids: A phenylalanine is missing at position 508. A baby is born with cystic fibrosis. He has an older brother. How would you test the DNA of the brother to determine if he is a carrier for cystic fibrosis? How would you design a gene therapy protocol to "cure" the cells in the lung and airway?

4. A number of efforts are underway to identify human genetic polymorphisms that correlate with complex diseases such as diabetes, heart disease and cancer. What would be the uses of such information? What concerns do you think are being raised by the people whose DNAs are being analyzed?

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