Childbirth is triggered by hormonal and mechanical stimuli

We traced the development of a human blastocyst into an embryo and then a fetus in Chapter 20. Throughout pregnancy, the muscles of the uterine wall periodically undergo slow, weak, rhythmic contractions called Braxton-Hicks contractions. These contractions become gradually stronger during the third trimester of pregnancy and are sometimes called false labor contractions. True labor contractions usually mark the beginning of childbirth. Both hormonal and mechanical stimuli contribute to the onset of labor.

43.14 Hormones Control the Ovarian and Uterine Cycles The ovarian and uterine cycles are under a complex series of positive and negative feedback controls involving several hormones.

Progesterone inhibits and estrogen stimulates contractions of uterine muscle. Toward the end of the third trimester, the estrogen-progesterone ratio shifts in favor of estrogen. The onset of labor is marked by increased oxytocin secretion by the pituitaries of both mother and fetus. Oxytocin is a powerful stimulant of uterine muscle contraction.

Mechanical stimuli come from the stretching of the uterus by the fully grown fetus and the pressure of the fetal head on the cervix. These mechanical stimuli increase the release of oxytocin by the posterior pituitary, which in turn increases the activity of uterine muscle, which causes even more pressure on the cervix. This positive feedback loop converts the weak, slow, rhythmic Braxton-Hicks contractions into stronger labor contractions (Figure 43.15).

In the early stage of labor, the contractions of the uterus are 15 to 20 minutes apart, and each lasts 45 to 60 seconds. During this time, the contractions pull the cervix open until it is large enough to allow the baby to pass through. Gradually the contractions become more frequent and more intense. This stage of labor lasts an average of 12 to 15 hours in a first pregnancy and 8 hours or less in subsequent ones.

The second stage of labor, called delivery, begins when the cervix is fully dilated. The baby's head moves into the vagina and becomes visible from the outside. The usual head-down position of the baby at the time of delivery comes about when the fetus shifts its orientation during the seventh month. If the fetus fails to move into the head-down position, a different part of the fetus enters the vagina first, and the birth is more difficult.

Passage of the fetus through the vagina is assisted by the mother's bearing down with her abdominal and other muscles to help push it along. Once the head and shoulders of the baby clear the cervix, the rest of its body eases out rapidly, but it is still connected to the placenta by the umbilical cord. Delivery may take as little as a minute, or up to half an hour or more in a first pregnancy.

As soon as the baby clears the birth canal, it can start breathing and become independent of its mother's circulation. The umbilical cord may then be clamped and cut. The segment still attached to the baby dries up and sloughs off in a few days, leaving behind its distinctive signature, the belly button—more properly called the umbilicus. The detachment and expulsion of the placenta and fetal membranes takes from a few minutes to an hour, and may be accompanied by uterine contractions. If the baby suckles at the breast immediately following birth, its suckling stimulates additional secretion of oxytocin, which augments uterine contractions that reduce the size of the uterus and help stop bleeding.

The release of oxytocin by the posterior pituitary increases the contractions of the uterus during labor and birth (a positive feedback loop).

Increased contractility of uterine muscle

Increased stretch of uterus

Labor Contraction Feedback Loop
43.15 Control of Uterine Contractions and Childbirth Both mechanical and hormonal signals are involved in the onset of childbirth.

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Pregnancy And Childbirth

Pregnancy And Childbirth

If Pregnancy Is Something That Frightens You, It's Time To Convert Your Fear Into Joy. Ready To Give Birth To A Child? Is The New Status Hitting Your State Of Mind? Are You Still Scared To Undergo All The Pain That Your Best Friend Underwent Just A Few Days Back? Not Convinced With The Answers Given By The Experts?

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