During his years as an undergraduate at Oxford, physics student Stephen Hawking took up rowing. Although he had never been much of an athlete, he was doing a passable job. But he noticed he was getting increasingly clumsy and by the time he went to Cambridge as a graduate student, he was falling over for no particular reason. After weeks of tests, his physicians told him that he had motor neuron disease, an incurable condition in which the nerve cells that stimulate muscles gradually die and the patient loses all muscular control.
As the years progressed, Hawking made major contributions to theoretical physics, especially to the study of black holes and the origin of the universe. He ascended the ladder of academic success and now holds a professorship at Cambridge once held by Isaac Newton. But his disease has gotten worse, and he has lost almost all muscular control.
A hallmark of living cells is their ability to regulate the substances that enter and leave them. This regulation is a function of the plasma membrane, which is composed of a hydrophobic lipid bilayer with associated proteins. Muscle cells respond to stimulation by nerve cells by opening protein-lined channels in their plasma membranes. Because his nerves cannot stimulate them, the channels of Hawk-ing's muscle cells do not open, and his muscles do not contract. Channels in plasma membranes underlie the biological activities of many organisms, ranging from the beating of an animal's heart to the opening of tiny pores in leaves to let outside air in.
Membranes are dynamic structures whose components move and change. They perform their vital physiological roles by allowing cells to interact with other cells and with molecules in the environment. We describe the structural aspects of those interactions here. Membranes also regulate the traffic of chemicals into and out of the cell. The selective permeability of membranes, which we describe in this chapter, is an important characteristic of life. Later in this book, we will see it in action in such diverse situations as the transduction of light energy into chemical energy in the chloroplast and the retention of water and ions in the mammalian kidney.
Was this article helpful?
Far too many people struggle to fall pregnant and conceive a child naturally. This book looks at the reasons for infertility and how using a natural, holistic approach can greatly improve your chances of conceiving a child of your own without surgery and without drugs!