Normal response

Nadir plasma glucose falls beneath 2.2 mmol/L (40 mg/100 ml). Serum cortisol rises by more than 170 nmol/L (6.0 ^g/dL) to above 550 nmol/L (20 ^g/dL). GH peak greater than 20 mU/L (8.0 ^g/L) in adults.

Note: This test is contraindicated in those with ischemic heart disease, epilepsy, or an unexplained history of loss of conciousness. Hypoadrenalism should be treated before performance of the test with omission of replacement corticosteroid the morning of the test. Prepubertal subjects undergoing testing of GH status should have androgen priming before testing.

* These endocrine-testing protocols have been developed over many years; a detailed summary of these and more tests is available in Trainer PJ, Besser GM. The Bart's Endocrine Protocols. Edinburgh, UK: Churchill Livingstone; 1995.45

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