Glucagon Test Procedure

Beta Switch Program

The Beta Switch Program by Sue Heintze

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Perform after an overnight fast omitting morning mediation

Weigh patient

Glucagon subcutaneous bolus at 09.00 h 1 mg <90 kg 1.5 mg >90 kg


Plasma glucose, serum Cortisol, and GH at -15, 0, 90, 120, 150, 180, 210, and 240 min.

Normal response

Plasma glucose rises to peak at 90 min.

Cortisol rises by more than 180 nmol/L (6.5 M-g/dL) to peak at greater than 550 nmol/L (20 Mg/dL).

Growth hormone rises to more than 20 mU/L (8.0 Mg/L).

Note: the test is contraindicated after a prolonged fast and in those with untreated hypoadrenalism.

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