Definition

Pituitary adenomas are commonly divided into "functioning" tumors (those that secrete pituitary hormones and cause clinical syndromes) and "nonfunctioning" tumors (those that do not secrete a pituitary hormone that leads to a clinical syndrome) (1). Tumors that do not secrete growth hormone (GH), adrenocorticotropic hormone (ACTH), prolactin, or thyroid-stimulating hormone (TSH) constitute the nonfunctioning pituitary tumors. Approximately 30% of pituitary adenomas are considered nonfunctioning by these criteria.

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