Clinical Presentation

By definition, nonfunctioning tumors do not have a clinical syndrome caused by hormone overproduction. Instead, nonfunctioning pituitary tumors present in patients with symptoms resulting from the size and location of the tumor, or symptoms of pituitary hormone deficiency, or a combination of these two effects (1).

When diagnosed, most of these tumors are macroadenomas (>1 cm in diameter), because there is no syndrome of hormone excess to bring them to medical attention when they are smaller.

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