Ideally, cell and gene restorative therapy in brain disorders should be able to completely reverse the disability without affecting the psyche of the patient compared to its status prior to the disease. Changes in personality undoubtedly occur in all brain diseases but also in normal life in relation to changes in circumstances and new experiences (see before). Changes are either directly or indirectly related to the disease. They are directly related when particular nervous functions are affected and indirectly related if the physical, psychological and social situation of patients is altered by the burden of the symptoms, limited potential of daily autonomous handling, fear, depression, stress, uncertainty about the future and a possible loss of self-respect and self-confidence. If the burden of the disease's symptoms can be eliminated, or alleviated, by neurorestorative interventions, many of these personality aspects will subsequently improve, simply because the patient feels better and healthier. These are welcome effects on their personality and not unwanted side effects. In this respect, these brain interventions are not different from a pharmaceutical therapy that aims to treat the origin of a disease. Neuro-active medication is often also prescribed to treat the symptoms of personality changes observed in psychiatric and neurological diseases the origin of which in the central nervous system cannot be precisely identified and localised. The possible negative consequences of the latter treatments, however, are largely reversible when medication is stopped. The question, therefore, remains whether cell or gene transfer will affect the neural regulatory body functions and the psyche in an unwanted and irreversible way.
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