Elevated white blood cell counts (WBCs) are associated with a higher risk of adverse events after an AMI. In the TIMI 10A and B trials (n = 975), an elevated WBC was associated with resistance to thrombolytic therapy, lower coronary artery patency at 60 and 90 min, worse TIMI myocardial perfusion grades and increased thrombus burden. When the WBC counts were > 15,000/^L, the 30-d mortality was 10.4% vs 0-4.9% for WBC counts <15,000/iL. Shock or heart failure was also more common in patients with higher WBC counts (17% vs 0-6%).
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