Timi Iiib

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As mentioned above, the TIMI IIIB trial used a 2 X 2 factorial design to compare tissue-type plasminogen activator and placebo and an early invasive strategy vs an early conservative strategy in patients with unstable angina or non-ST-elevation MI. A total of 1473 patients seen within 24 h of ischemic chest discomfort at rest, considered to represent unstable angina or non-ST-elevation MI, were included. All patients were treated with bed rest and anti-ischemic medications including aspirin, intravenous heparin, b-blockers, calcium channel blockers, and nitrates. Patients were then randomized into an early invasive strategy with early angiography (18-48 h), followed by revascularization when the anatomy was suitable, or an early conservative strategy with coronary angiog-raphy, followed by revascularization, used only if initial medical therapy failed. At 6 wk, the primary end point of death, MI, or an unsatisfactory symptom-limited exercise stress

Table 3

Trials Comparing Early Invasive and Conservative Strategies in Acute Coronary Syndromes

Table 3

Trials Comparing Early Invasive and Conservative Strategies in Acute Coronary Syndromes

Trial (reference)

Year

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