The relative mortality risk of patients with a previous MI is approx 1.5 X greater than in patients with a first infarction regardless of whether or not the patient is treated with thrombolytic therapy (9,11). The mortality gradient is greatest in patients with major left ventricular (LV) dysfunction prior to the reinfarction event. In TIMI II, a prior vs no prior history of MI was associated with 7.9 vs 4.3% mortality rate after 42 d (6). Mul-tivessel coronary disease was present in 60 vs 28% of patients with prior vs no prior infarction.
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