Plasma Fibrinolytic Factors

Lipoprotein (A) is composed of an LDL particle linked to a unique glycoprotein, apo A, which exhibits marked structural similarities to the plasma zymogen plasminogen. Experimental evidence suggests that increased levels of lipoprotein (A) impair fibrinolysis through binding to plasminogen receptors on fibrin, endothelial cells, mononuclear cells, and platelets.

Fig. 15. Vascular plasminogen activators and their inhibitors play an important role in both plaque activity (predisposing to disruption) and thrombosis. TPA, tissue plasminogen activator; (PAI-1), plas-minogen activator inhibitor.

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