Plasma Fibrinolytic Factors

Lipoprotein (A) is composed of an LDL particle linked to a unique glycoprotein, apo A, which exhibits marked structural similarities to the plasma zymogen plasminogen. Experimental evidence suggests that increased levels of lipoprotein (A) impair fibrinolysis through binding to plasminogen receptors on fibrin, endothelial cells, mononuclear cells, and platelets.

Fig. 15. Vascular plasminogen activators and their inhibitors play an important role in both plaque activity (predisposing to disruption) and thrombosis. TPA, tissue plasminogen activator; (PAI-1), plas-minogen activator inhibitor.

Was this article helpful?

0 0
Your Heart and Nutrition

Your Heart and Nutrition

Prevention is better than a cure. Learn how to cherish your heart by taking the necessary means to keep it pumping healthily and steadily through your life.

Get My Free Ebook


Post a comment