Pci

Refractory unstable angina, if PCI is to be performed within 24 h PCI:

Bolus: 0.25 mg/kg InfUsion: 0.125 ig/kg/min (max 10 ig/min) ACS + PCI (within 24 h) Same as above, for 12-24 h

EPIC, EPILOG, CAPTURE, EPISTENT, RAPPORT, ADMIRAL, CADILLAC, TARGET, GUSTO-IV, GUSTO-V

Integrilin

COR/Schering-Plough 1998

Cyclic heptapeptide

approx 2.5 h approx 50% renal NSTE ACS

ACS:

Bolus 180 ig/kg InfUsion: 2.0 ig/kg/min X 72-96 h PCI:

Bolus: 135 ig/kg Infusion 0.5 ig/kg/min X 20-24 h ESPRIT:

Bolus: 2x 180 ig/kg (10 min apart), then 2.0 ig/k/min X 18-24 h PURSUIT IMPACT-II

Aggrastat

Merck

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