I

Pathophysiology

The Spectrum of Myocardial Ischemia

The Paradigm of Acute Coronary Syndromes

Christopher P. Cannon, MD and Eugene Braunwald, MD

Contents

Introduction

Clinical Spectrum of ACS

Plaque Rupture

Inflammation

Thrombosis

Pathophysiologic Spectrum

Now Paradigm of Clinical Syndromes

STEMI: The Open Artery Theory

Paradigm for Non-STE ACS

Medical Treatment

Clinical Course

References

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