Anticoagulation Coagulation Cascade

Antithrombin Site Action

Thrombin is a glycosylated serine protease that plays a fundamental role in thrombosis 117 . Thrombin is generated from prothrombin by the prothrombinase complex, which includes factors Xa, Va, calcium, and phospholipids Fig. 7 . Its main action is to transform fibrinogen into fibrin. Thrombin is one of the most potent endogenous platelet activator 110-112 . The active catalytic site lies within a relatively narrow canyon on the molecule's surface Fig. 8 118 . Adjacent to this site is the...

National Heart Attack Alert Program

The new treatments and the synergistic effect of time on their effectiveness, coupled with ongoing patient and system delays, gave the impetus for the National Heart, Lung, and Blood Institute's (NHLBI's) consideration, in the late 1980s, of establishing a national education program dedicated to coordinating efforts to improve emergency care for patients with acute MI and their outcomes (9). The NHLBI launched the National Heart Attack Alert Program (NHAAP) in June 1991, with the first meeting...