Nitric Oxide

Nitric oxide, a potent biological mediator synthesized from L-arginine by the enzyme NO synthase (NOS), is a small lipophilic molecule that can diffuse rapidly across cell membranes. One form of NOS is neuronal NO synthase found in the nonadrenergic, noncholiner-gic nerves of the peripheral nervous system; a second is endothelial NO synthase; and the third is inducible NO synthase (Conboy and Jones, 2000). Inducible NO synthase can be induced by inflammation or infection and a range of cell types, by pro-inflammatory cy-tokines such as IFN-y, IL-1 (3 and TNF-y, by IgE immune complexes, or by bacterial products such as lipopoly-saccharide and lipotechoic acid, and by viral infections. In animal models, inducible NO synthase inhibitors reduce the late-phase response after allergen challenge. Inducible NO synthase knockout mice appear to have an enhanced TH1 phenotype with an increase in IFN-y and a decrease in IL-4. Inducible NO synthase inhibitors, therefore, have potential as anti-inflammatory agents in rhinitis.

Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

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