The Pathogens That Cause Gas Gangrene Clostridial Myonecrosis and Anaerobic Cellulitis

Pathogen spectrum. The pathogens that cause these clinical pictures include Clostridium perfringens, C. novyi, C. septicum, and C. histolyticum. Species observed less frequently include C. sporogenes, C. sordellii, and C. bifermentans. The most frequent causative pathogen in gas gangrene is C. perfringens.

Toxins, enzymes. The toxins produced by invasive clostridia show necro-tizing, hemolytic, and/or lethal activity. They also produce collagenases,

Clostridium perfringens and sporogenes

Clostridium perfringens and sporogenes

Perfringens

Fig. 4.7 a C. perfringens: gram staining of a preparation of wound pus. Large, thick, gram-positive rods. Clinical diagnosis: gas gangrene in a gunshot wound. b C. sporogenes: Spore staining of a preparation from an aged broth culture. Thick-walled spores stained red. Occasionally "tennis racquet" forms.

Fig. 4.7 a C. perfringens: gram staining of a preparation of wound pus. Large, thick, gram-positive rods. Clinical diagnosis: gas gangrene in a gunshot wound. b C. sporogenes: Spore staining of a preparation from an aged broth culture. Thick-walled spores stained red. Occasionally "tennis racquet" forms.

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Essentials of Human Physiology

Essentials of Human Physiology

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  • Rosario
    How clostridial myonecrosis causes gas gangrene?
    8 years ago

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