Causative agent of isosporosis

The causative agent of human isosporiosis is Isospora belli. After peroral ingestion of sporulated oocysts and release of sporozoites, further development (schizogony, gamogony) takes place in the epithelium of the upper small intestine, leading finally to oocyst formation. In AIDS patients, encysted sporozoites have been found in various extraintestinal organs (lymph nodes, liver, gallbladder, spleen).

I. belli can cause severe clinical symptoms, especially in AIDS patients, for example persistent diarrhea, steatorrhea, cholecystitis, weight loss, and fever. Diagnosis is made by detection of unsporulated oocysts (20-30 im long) in stool (Fig. 9.111, p. 504) or of developmental stages in intestinal biopsies. High-dosed cotrimoxazole is the recommended therapy.

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Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

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