This involves in-vitro antigen stimulation, and consequent proliferation, of patient T-cell effector clones or populations (CD8+ T cells or less specific lymphokine-activated killer cells, LAK cells), followed by transfusion of these cells back into the patient. This method is sometimes used as a means of limiting cytomegaly or Epstein-Barr virus infection of bone marrow recipients. The LAK cells also include less specific NK-like cells, which can be expanded with 1L-2 in the absence of antigen stimulation.
Toxic antibodies are monoclonal antibodies to which toxins have been coupled. These are used as specific toxin transporters, administered directly, or with liposomes bearing anchored antibodies and containing a toxin or cytostatic drug.
Kayser, Medical Microbiology © 2005 Thieme
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Immunological Test Methods
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