Filling and Evaporation

Delivering perfluorocarbon to the lung is a tedious procedure. The drug must be slowly dripped into the airway to avoid obstruction by air locks in the distal lung. Hypoxemia, tachycardia, and hyper or hypotension are common during filling if care is not exercised. Since perfluorocarbons have a high vapor pressure, they readily evaporate [24] removing the drug from the lung within 48 hours of the last dose. Repeat dosing is required every 2 to 4 hours to maintain an appropriate drug level.

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