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Front cover photographs: (Top) In situ hybridization showing expression of collagenase-1 (MMP-1) by adventitial fibroblasts in a developing pulmonary artery from a 210-day fetal calf. Photomicrograph provided by William C. Parks. (Center) As detected by in situ hybridization, matrilysin (MMP-7) is prominently expressed by Paneth cells in the crypts of mouse ileum. Photomicrograph from Wilson et al., 1995, used with permission. (Bottom) At the point of epidermal separation in blister formation, gelatinase-B (MMP-9) is produced and released by eosinophils. Photomicrograph provided by Mona St&hle-Backdahl.

Wilson, C. L„ Heppner, K. J., Rudolph, L. A., and Matrisian, L. M. (1995). The metalloproteinase matrilysin is preferentially expressed by epithelial cells in a tissue-restricted pattern in the mouse. Mol. Biol. Cell 6, 851- 869.

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