Summary of Clinical Results

Numerous studies attest to the applicability and clinical success of both TOF MRA (Table 5) and moving-table CE-MRA (Table 6). Of importance is

Table 5. Accuracy of 2D TOF MRA for significant (>50%) stenosis or occlusion by territory

Author

Year

# Patients

# Segments

Sens(%)

Spec (%)

Aorto-iliac arteries:

Baumgartner

1993

15

15

82

100

Glickerman

1996

23

161

89

98

Snidow

1996

42

68

100

23

Quinn

1993

30

118

94

91

Yucel

1993

25

93

93

83

Poon

1997

15

90

100

86

Femoro-popliteal arteries:

Baumgartner

1993

15

26

88

100

Glickerman

1996

23

324

88

98

Snidow

1996

42

170

92

82

Yucel

1993

25

82

93

92

Infra-popliteal arteries:

Glickerman

1996

23

384

86

91

Snidow

1996

42

88

92

91

McDermott

1995

24

216

89

91

Table 6. Accuracy of 2D TOF MRA for significant (>50%) stenosis or occlusion by territory

Author

Year

# Patients

# Segments

Sens (%)

Spec (%)

Ho

1997

28

242

92

93

Yamashita

1998

20

140

96

83

Meaney

1999

20

620

85

93

Ruehm

2001

61

1739

92

98

Rofsky

2000

15

150

97

96

Table 7. Summary of results of three recent meta-analyses

Technique studies

# Patients

# Segments

Sens (%)

Spec (%)

DOR*

Nelemans[52]

2D TOF

13

344

64-100

68-96

1.0

3D CE-MRA

10

253

92-100

91-99

7.46

Koelemay[53]

2D TOF

18

474

69-100

73-97

1.0

3D CE-MRA

482

85-97

83-98

2.8

Visser & Hunink [54]

3D CE-MRA

9

216

97.5

96.2

Duplex US

18

1059

87.6

94.7

*The diagnostic odds ratio (DOR) a powerful method for comparing techniques and gives the odds of a positive test in a diseased person compared to the odds if a diseased test in a non-diseased person

*The diagnostic odds ratio (DOR) a powerful method for comparing techniques and gives the odds of a positive test in a diseased person compared to the odds if a diseased test in a non-diseased person the fact that peripheral MRA has been subjected to three meta-analyses of the reported literature (Table 7) [52-54].

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