It has been suggested that patients with a relatively low tumor burden may benefit most from adjuvant treatment strategies . If effective schedules should become available, for instance in the form of interferon-alpha in a tolerable dose  or a vaccine , micrometastasis detected by sentinel lymphadenectomy may prove to be an attractive selection criterion for these adjuvant treatments.
In this respect, the relevance of the RT-PCR technique for the detection of tyrosinase or other specific markers for the presence of melanoma cells in the sentinel lymph node has to be elucidated [9,27]. In one report, RT-PCR positivity in histologically negative sentinel nodes was associated with a recurrence rate of 10.6%, compared to a rate of 2.3% in RT-PCR-negative patients . This suggests that RT-PCR is of practical value in melanoma staging and therefore could be a selection criterion for entering patients in adjuvant treatment schedules.
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Complete Guide to Preventing Skin Cancer. We all know enough to fear the name, just as we do the words tumor and malignant. But apart from that, most of us know very little at all about cancer, especially skin cancer in itself. If I were to ask you to tell me about skin cancer right now, what would you say? Apart from the fact that its a cancer on the skin, that is.