Krag et al. published the first pilot study of sentinel lymphadenectomy in patients with invasive breast cancer . In this study, an unfiltered technetium-99m (99mTc)-labeled colloid was injected 1-9 h prior to surgery and was used to map the lymphatic tract and identify the sentinel node. The sentinel node was identified in 82% of a group of 22 patients using a hand-held gamma-ray counter. The sentinel node proved 100% predictive of the axillary status. This implies that if this node is free of disease, the remainder of the axillary nodes are also free of disease. Krag and co-workers updated their results in 248 cases . The sentinel node was identified in 95.5% of patients with a false-negative rate of 6.5%. This led to the initiation of a multicenter trial to evaluate the success of intraoperative lymphatic mapping and sentinel lymphadenectomy using a radiolabeled colloid. The results of this trial have recently been reported and show a false-negative sentinel lymph node biopsy rate of 11.4% in a multicenter trial involving 12 institutions .
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Complete Guide to Preventing Skin Cancer. We all know enough to fear the name, just as we do the words tumor and malignant. But apart from that, most of us know very little at all about cancer, especially skin cancer in itself. If I were to ask you to tell me about skin cancer right now, what would you say? Apart from the fact that its a cancer on the skin, that is.