Thomas Ritter and Hans Dieter Volk Abstract

Organ transplantation has been developed as ultimative option in patients with end-stage organ diseases. New immunosuppressive regimens and improved perioperative management did improve the short-term results during the last decade, however, insufficient control of chronic rejection and side effects of continuous immunosuppression limit the long-term success of this approach. The immunosuppressive drugs used today suppress both unspecific inflammatory reactions and specific T-cell activation. Unfortunately, these powerful drugs also prevent the activation of the endogenous counterregulatory processes that control the immune response (e.g., regulatory T cells, anti-inflammatory cytokines). Thus, targeting more selective the inflammatory process would be of outstanding interest.

IL-10 might be an ideal candidate for this approach as it expresses both direct anti-inflammatory and immunoregulatory properties. Therefore, IL-10 has been administered in various models of cell and organ transplantation using different ways of application which will be discussed in the following chapter.

Was this article helpful?

0 0
Cure Tennis Elbow Without Surgery

Cure Tennis Elbow Without Surgery

Everything you wanted to know about. How To Cure Tennis Elbow. Are you an athlete who suffers from tennis elbow? Contrary to popular opinion, most people who suffer from tennis elbow do not even play tennis. They get this condition, which is a torn tendon in the elbow, from the strain of using the same motions with the arm, repeatedly. If you have tennis elbow, you understand how the pain can disrupt your day.

Get My Free Ebook


Post a comment