Rationale of IL10 Application in Transplantation

In principle, IL-10 has been used in experimental transplantation in three different ways: • donor pretreatment with recombinant IL-10 or systemic gene therapy with the aim to reduce the ischemia/reperfusion injury and the graft immunogenicity by deactivating donor intragraft macrophages and antigen-presenting cells.

Figure 1. The different ways of IL-10 application in transplantation are shown. Abbreviations: IRI= is-chemia-/reperfusion injury; gene therapy; fj^jl : IL-10 protein; \l : reduction of ; ^^ : transplant.

• recipient treatment with recombinant IL-10 or systemic gene therapy with the aim to prevent acute graft rejection by deactivating inflammatory reactions and inducing regulatory T cells.

• gene therapy resulting in intragraft over-expression of IL-10 with the aim to combat both ischemia/reperfusion injury and T-cell mediated graft rejection by combination of the effects described above.

Protective IL-10 can also be induced indirectly, e.g., by application of cAMP elevating drugs like prostaglandins or 15-deoxyspergualin5 but these approaches will not be discussed in this review.

Was this article helpful?

0 0
Natural Treatments For Psoriasis

Natural Treatments For Psoriasis

Do You Suffer From the Itching and Scaling of Psoriasis? Or the Chronic Agony of Psoriatic Arthritis? If so you are not ALONE! A whopping three percent of the world’s populations suffer from either condition! An incredible 56 million working hours are lost every year by psoriasis sufferers according to the National Psoriasis Foundation.

Get My Free Ebook

Post a comment