Macrophages

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Macrophages appear to be the predominant source of IL-10 in the lungs. Human alveolar macrophages spontaneously release IL-10 and this is increased by inflammatory stimuli, such as interleukin(IL)-1P and endotoxin.7,8 Alveolar macrophages from asthmatic patients release significantly less IL-10 at baseline and in response to inflammatory stimuli than cells from normal subjects.8 A similar pattern is observed with monocytes from peripheral blood and this defect in IL-10 secretion is more marked in patients with severe compared to mild asthma, suggesting that this deficit may relate to the severity of asthma and the intensity of airway inflammation.9

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Coping with Asthma

Coping with Asthma

If you suffer with asthma, you will no doubt be familiar with the uncomfortable sensations as your bronchial tubes begin to narrow and your muscles around them start to tighten. A sticky mucus known as phlegm begins to produce and increase within your bronchial tubes and you begin to wheeze, cough and struggle to breathe.

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